Colgate® Total® significantly reduces inflammation in patients with peri-implant mucositis vs. ordinary fluoride toothpaste.
Sixty male and female subjects, aged 30-70 years were enrolled in a 6-month, double-blind, randomized, 2-treatment, parallel-group clinical study. All subjects had lost teeth due to periodontal disease, and had been restored with a minimum of 2 implants at least 1 year prior to the start of the trial. All subjects had a minimum of 1 site with clinical signs of peri-implant mucositis.
Subjects were randomly assigned to 2 treatment groups. The subjects in the Test group, brushed their teeth and implant-supported restorations with Colgate® Total® (triclosan/copolymer). The control group brushed with ordinary fluoride toothpaste (sodium fluoride). Only subjects with a minimum of 1 implant site showing clinical signs of peri-implant mucositis (i.e., bleeding after probing) were enrolled in the study. Probing pocket depth (PPD), bleeding on probing (BoP), and plaque parameters were assessed. Characteristics excluding patients from the study included untreated periodontal disease, carious lesions requiring immediate restorative treatment, use of antibiotics 1 month prior to entry into the study, untreated peri-implantitis, women who were pregnant or breast feeding, history of allergies to personal care/consumer products or their ingredients, medical condition that prohibits not eating or drinking for up to 2 hours, uncontrolled diabetes, and regular use of anti-inflammatory drugs. Clinical examinations were performed at baseline, and after 3 and 6 months.
Subjects with peri-implant mucositis who used Colgate® Total® (triclosan/copolymer) as an adjunct to mechanical tooth brushing, exhibited significantly fewer clinical signs of inflammation than subjects who used ordinary fluoride toothpaste (sodium fluoride) at 6 months. At 6 months, the BoP scores in the Colgate® Total® group were significantly reduced vs baseline (P<0.001) and vs the ordinary fluoride toothpaste group. BoP for the ordinary fluoride toothpaste group actually increased from baseline to 6 months. Individual mean PPD, as well as the frequency of sites with 5 mm and ≥6 mm deep pockets, were reduced significantly more in the Colgate® Total® group than in the ordinary fluoride toothpaste group. The regular use of Colgate® Total® may reduce the clinical signs of inflammation in the mucosa adjacent to dental implants.
Ramberg P, Lindhe J, Botticelli D, Botticelli A. The effect of a triclosan dentifrice on mucositis in subjects with dental implants: a six-month clinical study. J Clin Dent. 2009;20(3):103-107.